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Jump to Book Chapters and Review Papers

Primary Publications:

  1. Narahari, T.; Dahmer, J.; Sklavounos, A.; Kim, T.; Satkauskas, M.; Clotea, I.; Ho, M.; Lamanna, J.; Dixon, C.; Rackus, D.G.; Silva, S.J.R.d.; Pena, L.; Pardee, K.; Wheeler, A.R. "Portable Sample Processing for Molecular Assays: Application to Zika Virus Diagnostics" Lab Chip 2022, 22, 1748-1763. Supporting Info.
  2. Zhang, S.; Elsayed, M.; Peng, R.; Chen, Y.; Zhang, Y.; Neale, S.L.; Wheeler, A.R "Influence of Light Pattern Thickness on the Manipulation of Dielectric Microparticles by Optoelectronic Tweezers" Photonics Research 2022, 10, 550-556. Supplementary Movie.
  3. Li, B.B.; Scott, E.Y.; Olafsen, N.E.; Matthews, J.; Wheeler, A.R. "Analysis of the Effects of Aryl Hydrocarbon Receptor Expression on Cancer Cell Invasion via Three-Dimensional Microfluidic Invasion Assays" Lab Chip 2022, 22, 313–325. Supporting Info.
  4. Shuzhang Liang; Gan, C.; Dai, Y.; Zhang, C.; Bai, X.; Zhang, S.; Wheeler, A.R.; Chen, H.; Feng, L. "Interaction between Positive and Negative Dielectric Microparticles/Microorganism in Optoelectronic Tweezers" Lab Chip 2021, 21, 4379–4389.
  5. Sklavounos, A.A.; Lamanna, J.; Modi, D.; Gupta, S.; Mariakakis, A.; Callum, J.; Wheeler, A.R. "Digital Microfluidic Hemagglutination Assays for Blood Typing, Donor Compatibility Testing, and Hematocrit Analysis" Clin. Chem. 2021, 67, 1699–1708. Supplementary: Info, Movie.
  6. Sklavounos, A.A.; Nemr, C.R.; Kelley, S.O.; Wheeler, A.R. "Bacterial Classification and Antibiotic Susceptibility Testing on an Integrated Microfluidic Platform" Lab Chip 2021, 21, 4208 - 4222. Supporting Info.
  7. Zhang, S.; Li, W.; Elsayed, M.; Peng, J.; Chen, Y.; Zhang, Y.; Zhang, Y.; Shayegannia, M.; Dou, W.; Wang, T.; Sun, Y.; Kherani, N.P.; Neale, S.L.; Wheeler, A.R. "Integrated Assembly and Photopreservation of Topographical Micropatterns" Small , 2021, 17, 2103702. Supporting info, Supporting video
  8. Zhang, S.; Elsayed, M.; Peng, R.; Chen, Y.; Zhang, Y.; Peng, J.; Li, W.; Chamberlain, M.D.; NIkitina, A.; Yu, S.; Liu, X.; Neale, S.L.; Wheeler, A.R. "Reconfigurable Multi-Component Micromachines Driven by Optoelectronic Tweezers" Nature Comm. , 2021, 12, 5349. Supporting info, Supporting video
  9. Peng, R.; Pan, Y.; Liu, B.; Li, Z.; Pan, P.; Zhang, S.; Qin, Z.; Wheeler, A.R.; Tang, X.S.; Liu, X "Understanding Carbon Nanotube-Based Ionic Diodes: Design and Mechanism" Small, 2021, 17, 2100383. Supplementary: Info.
  10. Lamanna, J.; Scott, E.Y.; Edwards, H.S.; Chamberlain, M.D.; Dryden, M.D.M.; Peng, J.; Mair, B.; Lee, A.; Chan, C.; Sklavounos, A.A.; Heffernan, A.; Abbas, F.; Lam, C.; Olson, M.E.; Moffat, J.; Wheeler, A.R. "Digital Microfluidic Isolation of Single Cells for -Omics" Nature Comm., 2020, 11, 5632. Supplementary: Info, Movie 1, Movie 2.
  11. Sathyanarayanan, G.; Haapala, M.; Dixon, C.; Wheeler, A.R.; Sikanen, T.M. "A Digital-to-Channel Microfluidic Interface via Inkjet Printing of Silver and UV Curing of Thiol–Enes" Adv. Mater. Tech. , 2020, 5, 2000451. Supporting info. Supporting video.
  12. Peng, R.; Pan, Y.; Li, Z.; Zhang, S.; Wheeler, A.R.; Tang, X.S.; Liu, X. "Ionotronics Based on Horizontally Aligned Carbon Nanotubes" Adv. Func. Mater. 2020, 30, 2003177.
  13. Li, B.B.; Scott, E.Y.; Chamberlain, M.D.; Duong, B.T.V.; Zhang, S.; Done, S.J.; Wheeler, A.R. "Cell Invasion in Digital Microfluidic Microgel Systems" Science Advances. 2020, 6, eaba9589. Supporting Info.
  14. Dixon, C.; Lamanna, J.; Wheeler, A.R. "Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device" Lab on a Chip. 2020, 20, 1845-1855. Supplementary: Info, Movie.
  15. Zhang, S.; Zhai, Y.; Peng, R.; Shayegannia, M.; Flood, A.G.; Qu, J.; Liu, X.; Kherani, N.P.; Wheeler, A.R. "Assembly of Topographical Micropatterns with Optoelectronic Tweezers" Adv. Optical Mater. 2019, 7(20), 1900669. Supplementary: Info, Movie.
  16. Wu, B.; von der Ecken, S.; Swyer, I.; Li, C.; Jenne, A.; Vincent, F.; Schmidig, D.; Kuehn, T.; Beck, A.; Busse, F.; Stronks, H.; Soong, R.; Wheeler, A.R.; Simpson, A. "Rapid Chemical Reaction Monitoring by Digital Microfluidics-NMR: Proof of Principle Towards an Automated Synthetic Discovery Platform" Angew. Chem. Int. Ed. 2019, 58, 15372-15376. Supporting Info.
  17. Zhang, S.; Li, W.; Elsayed, M.; Tian, P.; Clark, A.W.; Wheeler, A.R.; Neale, S.L. "Size-scaling effects for microparticles and cells manipulated by optoelectronic tweezers" Optics Letters, 2019, 44 (17), 4171-4174. Supplementary: Movie 1, Movie 2, Movie 3.
  18. Zhang, S.; Scott, E.Y.; Singh, J.; Chen, Y.; Zhang, Y.; Elsayed, M.; Chamberlain, M.D.; Shakiba, N.; Adams, K.; Yu, S.; Morshead, C.M.; Zandstra, P.W.; Wheeler, A.R. "The optoelectronic microrobot: A versatile toolbox for micromanipulation" Proceedings of the National Academy of Science, U.S.A. 2019, 116 (30), 14823-14828. Supporting Info, Supplementary Movies.
  19. Rahbar, M.; Wheeler, A.R.; Paul, B.; Macka M. "Ion-Exchange Based Immobilization of Chromogenic Reagents on Microfluidic Paper Analytical Devices" Analytical Chemistry 2019, 91, 8756-8761. Supporting Info.
  20. Swyer, I.; Fobel, R.; Wheeler, A.R. "Velocity Saturation in Digital Microfluidics" Langmuir 2019, 35, 5342-5352. Supplementary: Info, Movie 1, Movie 2, Movie 3.
  21. Yu, Y.; Campos, R.P.S.d.; Hong, S.; Kraste, D.L.; Sadanand, S.; Leung, Y.; Wheeler, A.R. "A Microfluidic Platform for Continuous Monitoring of Dopamine Homeostasis in Dopaminergic Cells" Microsyst. Nanoeng. 2019, 5, 10. Supplementary:Supporting info.
  22. Swyer, I.; Ecken, S.v.d.; W, B.; Jenne, A.; Soong, R.; Vincent, F.; Schmidig, D.; Frei, T.; Busse, F.; Stronks, H.J.; Simpson, A.J.; Wheeler, A.R. "Digital Microfluidics and Nuclear Magnetic Resonance Spectroscopy for in situ Diffusion Measurements and Reaction Monitoring" Lab Chip 2019, 19, 641-653. Supporting info.
  23. Campos, R.P.S.d.; Darius G. Rackus; Shih, R.; Chen Zhao; Liu, X.; Wheeler, A.R. "'Plug-n-Play' Sensing with Digital Microfluidics" Anal. Chem. 2019, 91, 2506−2515. Supporting info.
  24. Zhang, S.; Shakiba, N.; Chen, Y.; Zhang, Y.; Tian, P.; Singh, J.; Chamberlain, M.D.; Satkauskas, M.; Flood, A.G.; Kherani, N.P.; Yu, S.; Zandstra, P.W.; Wheeler, A.R. "Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells" Small, 2018, 45, 1803342. Supplementary: Info, Movie 1, Movie 2, Movie 3, Movie 4, Movie 5, Movie 6.
  25. Ng, A.H.C.; Fobel, R.; Fobel, C.; Lamanna, J.; Rackus, D.G.; Summers, A.; Dixon, C.; Dryden, M.D.M.; Lam, C.; Ho, M.; Mufti, N.S.; Lee, V.; Asri, M.A.M.; Sykes, E.A.; Chamberlain, D.; Joseph, R.; Ope, M.; Scobie, H.M.; Knipes, A.; Rota, P.A.; Marano, N.; Chege, P.M.; Njuguna, M.; Nzunza, R.; Kisangau, N.; Kiogora, J.; Karuingi, M.; Burton, J.W.; Borus, P.; Lam, E.; Wheeler, A.R."A Digital Microfluidic System for Serological Immunoassays in Remote Settings" Sci. Trans. Med. 2018, 10, eaar6076. Supplementary Materials.
  26. Zhang, S.; Nikitina, A.; Chen, Y.; Zhang, Y.; Liu, L.; Flood, A.G.; Juvert, J.; Chamberlain, M.D.; Kherani, N.P.; Neale, S.L.; Wheeler, A.R. "Escape from an optoelectronic tweezer trap: experimental results and simulations" Optics Express, 2018, 26, 5300-5309. Supplementary: Movie 1, Movie 2; Movie 3; Movie 4.
  27. Rackus, D.G.; P. S. de Campos, R.; Chan, C.; Karcz, M.M.; Seale, B.; Narahari, T.; Dixon, C.; Chamberlain, M.D.; Wheeler, A.R. "Pre-Concentration by Liquid Intake by Paper (P-CLIP): A New Technique for Large Volumes and Digital Microfluidics" Lab on a Chip, 2017, 17, 2272-2280. Supporting info.
  28. Abdulwahab, S.; Ng, A.H.C.; Chamberlain, M.D.; Ahmado, H.; Behan, L.-A.; Gomaa, H.; Casper, R.F.; Wheeler, A.R. "Towards a Personalized Approach to Aromatase Inhibitor Therapy: A Digital Microfluidic Platform for Rapid Analysis of Estradiol in Core-Needle-Biopsies" Lab on a Chip, 2017, 17, 1594-1602.
  29. Dixon, C.; Ng, A.H.C.; Fobel, R.; Miltenburg, M.B.; Wheeler, A.R. "An Inkjet Printed, Roll-Coated Digital Microfluidic Device for Inexpensive, Miniaturized Diagnostic Assays" Lab on a Chip, 2016, 16, 4560-4568. Supporting info. Supporting video.
  30. Swyer, I.; Soong, R.; Dryden, M.D.M.; Fey, M.; Maas, W.E.; Simpson, A.; Wheeler, A.R. "Interfacing Digital Microfluidics with High-Field Nuclear Magnetic Resonance Spectroscopy" Lab on a Chip, 2016, 16, 4424-4435. Supporting info.
  31. Seale, B.; Lam, C.; Rackus, D.G.; Chamberlain, M.D.; Liu, C.; Wheeler, A.R. "Digital Microfluidics for Immunoprecipitation" Analytical Chemistry, 2016, 88, 10223-10230. Supporting info.
  32. Choi, K.; Boyacı, E.; Kim, J.; Seale, B.; Barrera-Arbelaez, L.; Pawliszyn, J.; Wheeler, A.R. "A Digital Microfluidic Interface between Solid-Phase Microextraction and Liquid Chromatography–Mass Spectrometry" J. Chromatogr. A, 2016, 1444, 1-7. Supporting info.
  33. Zhang, B.; Montgomery, M.; Chamberlain, M.D.; Ogawa, S.; Korolj, A.; Pahnke, A.; A.Wells, L.; Massé, S.; Kim, J.; Reis, L.; Momen, A.; Nunes, S.S.; Wheeler, A.R.; Nanthakumar, K.; Keller, G.; Sefton, M.V.; Radisic, M. "Biodegradable Scaffold with Built-in Vasculature for Organ-on-a-Chip Engineering and Direct Surgical Anastomosis" Nature Materials, 2016, 15, 669-678.
  34. Yu, Y.; Shamsi, M.H.; Krastev, D.L.; Dryden, M.D.M.; Leung, Y.; Wheeler, A.R. "A Microfluidic Method for Dopamine Uptake Measurements in Dopaminergic Neurons" Lab Chip 2016, 16, 543-552. Supporting info
  35. Liu, C.; Choi, K.; Kang, Y.; Kim, J.; Fobel, C.; Seale, B.; Campbell, J.L.; Covey, T.R.; Wheeler, A.R. "Direct Interface between Digital Microfluidics and High Performance Liquid Chromatography–Mass Spectrometry" Analytical Chemistry, 2015, 87, 11967-11972. Supporting info.
  36. Shamsi, M.H.; Choi, K.; Ng, A.H.C.; Chamberlain, M.D.; Wheeler, A.R. "Electrochemiluminescence on Digital Microfluidics for MicroRNA Analysis" Biosensors and Bioelectronics, 2015, 77, 845-852. Supporting info.
  37. Dryden, M.D.M.; Wheeler, A.R. "DStat: A Versatile, Open-Source Potentiostat for Electroanalysis and Integration" PLoS ONE, 2015, 10, e0140349. Supporting info. Movie.
  38. Choi, K.; Mudrik, J.M.; Wheeler, A.R. "A Guiding Light: Spectroscopy on Digital Microfluidic Devices Using in-Plane Optical Fibre Waveguides" Anal. Bioanal. Chem. 2015, 407, 7467-7475. Supporting info.
  39. Rackus, D.G.; Dryden, M.D.M.; Lamanna, J.; Zaragoza, A.; Lam, B.; Kelley, S.O.; Wheeler, A.R. "A Digital Microfluidic Device with Integrated Nanostructured Microelectrodes for Electrochemical Immunoassays" Lab on a Chip, 2015, 15, 3776-3784. Supporting info.
  40. Ng, A.H.C.; Chamberlain, M.D.; Situ, H.; Lee, V.; Wheeler, A.R. "Digital microfluidic immunocytochemistry in single cells" Nat. Commun., 2015, 6, 7513. Supplementary: Info, Movie 1, Movie 2, Movie 3, Movie 4.
  41. Kim, J.; Abdulwahab, S.; Choi, K.; Lafreniere, N.M.; Mudrik, J.M.; Gomaa, H.; Ahmado, H.; Behan, L.-A.; Casper, R.F.; Wheeler, A.R. "A Microfluidic Technique for Quantification of Steroids in Core Needle Biopsies" Analytical Chemistry, 2015, 87, 4688-4695. Supporting info.
  42. Lafreniere, N.M.; Mudrik, J.M.; Ng, A.H.C.; Seale, B.; Spooner, N.; Wheeler, A.R. "Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments" Analytical Chemistry, 2015, 87, 3902-3910.
  43. Ng, A.H.C.; Lee, M.; Choi, K.; Fischer, A.T.; Robinson, J.M.; Wheeler, A.R. "A Digital Microfluidic Platform for the Detection of Rubella Infection and Immunity: A Proof of Concept" Clin. Chem., 2015, 61, 420-429. Supporting info. Supporting video.
  44. Sarvothaman, M.K.; Kim, K.S.; Seale, B.; Brodersen, P.M.; Walker, G.C.; Wheeler, A.R. "Dynamic Fluoroalkyl Polyethylene Glycol Co-Polymers: A New Strategy for Reducing Protein Adhesion in Lab-on-a-Chip Devices" Adv. Func. Mater., 2015, 25, 506-515. Supporting info.
  45. Mei, N.; Seale, B.; Ng, A.H.C.; Wheeler, A.R.; Oleschuk, R. "Digital Microfluidic Platform for Human Plasma Protein Depletion" Analytical Chemistry, 2014, 86, 8466-8472. Supporting info. Supporting video.
  46. Au, S.H.; Chamberlain, M.D.; Mahesh, S.; Sefton, M.V.; Wheeler, A.R. "Hepatic organoids for microfluidic drug screening" Lab on a Chip, 2014, 14, 3290-3299. Supporting info.
  47. Shih, S.C.C.; Mufti, N.S.; Chamberlain, M.D.; Kim, J.; Wheeler, A.R. "A droplet-based screen for wavelength-dependent lipid production in algae" Energy & Environmental Science, 2014, 7, 2366-2375. Supporting info, supporting video.
  48. Kirby, A.E.; Lafrenière, N.M.; Seale, B.; Hendricks, P.I.; Cooks, R.G.; Wheeler, A.R. "Analysis on the Go: Quantitation of Drugs of Abuse in Dried Urine with Digital Microfluidics and Miniature Mass Spectrometry" Analytical Chemistry, 2014, 86, 6121-6129. Supporting video.
  49. Fobel, R.; Kirby, A.E.; Ng, A.H.C.; Farnood, R.R.; Wheeler, A.R. "Paper Microfluidics Goes Digital" Adv. Mat. 2014, 26, 2838-2843. Supporting info.
  50. Eydelnant, I.A.; Li, B.B.; Wheeler, A.R. "Microgels on-DemandNat. Commun. 2014, 5, 3355. Supplementary: Figures, Movie 1, Movie 2.
  51. Mudrik, J.M.; Dryden, M.D.M.; Lafrenière, N.M.; Wheeler, A.R. "Strong and small: strong cation-exchange solid-phase extractions using porous polymer monoliths on a digital microfluidic platform" Canadian Journal of Chemistry 2014, 92, 179-185.
  52. Lafrenière, N.M.; Shih, S.C.C.; Abu-Rabie, P.; Jebrail, M.J.; Spooner, N.; Wheeler, A.R. "Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics" Bioanalysis 2014, 6, 307-318.
  53. Shamsi, M.H.; Choi, K.; Ng, A.H.C.; Wheeler, A.R. "A digital microfluidic electrochemical immunoassay" Lab on a Chip 2014, 14, 547-554.
  54. Choi, K.; Ng, A.H.C.; Fobel, R.; Chang-Yen, D.A.; Yarnell, L.E.; Pearson, E.L.; Oleksak, C.M.; Fischer, A.T.; Luoma, R.P.; Robinson, J.M.; Audet, J.; Wheeler, A.R. "Automated Digital Microfluidic Platform for Magnetic-Particle-Based Immunoassays with Optimization by Design of Experiments" Analytical Chemistry 2013, 85, 9638-9646. Supporting info.
  55. Dryden, M.D.M.; Rackus, D.G.; Shamsi, M.H.; Wheeler, A.R. "Integrated Digital Microfluidic Platform for Voltammetric Analysis" Analytical Chemistry 2013, 85, 8809-8816.
  56. Au, S.H.; Fobel, R.; Desai, S.P.; Voldman, J.; Wheeler, A.R. "Cellular bias on the microscale: probing the effects of digital microfluidic actuation on mammalian cell health, fitness and phenotype" Integr. Biol. 2013, 5, 1014. Supporting info.
  57. Kirby, A.E.; Wheeler, A.R. "Microfluidic Origami: A New Device Format for In-Line Reaction Monitoring by Nanoelectrospray Ionization Mass Spectrometry" Lab on a Chip 2013, 13, 2533-2540.
  58. Chen, M.B.; Srigunapalan, S.; Wheeler, A.R.; Simmons, C.A. "A 3D Microfluidic Platform Incorporating Methacrylated Gelatin Hydrogels to Study Physiological Cardiovascular Cell–Cell Interactions" Lab on a Chip 2013, 13, 2591-2598.
  59. Fobel, R.; Fobel, C.; Wheeler, A.R. "Dropbot: An Open-Source Digital Microfluidic Control System with Precise Control of Electrostatic Driving Force and Instantaneous Drop Velocity MeasurementAppl. Phys. Lett. 2013, 102, 193513. Supporting info.
  60. Shih, S.C.C.; Barbulovic-Nad, I.; Yang, X.; Fobel, R.; Wheeler, A.R. "Digital Microfluidics with Impedance Sensing for Integrated Cell Culture and Analysis" Biosens. Bioelectron. 2013, 42, 314–320. Supporting info
  61. Ng, A.H.C.; Choi, K.; Luoma, R.P.; Robinson, J.M.; Wheeler, A.R. "Digital Microfluidic Magnetic Separation for Particle-Based Immunoassays" Analytical Chemistry 2012, 84, 8805-8812. Supporting info
  62. Jebrail, M.J.; Assem, N.; Mudrik, J.M.; Dryden, M.D.M.; Lin, K.; Yudin, A.K.; Wheeler, A.R. "Combinatorial Synthesis of Peptidomimetics Using Digital Microfluidics" Journal of Flow Chemistry 2012, 2, 103-107.
  63. Shih, S.C.C.; Yang, H.; Jebrail, M.J.; Fobel, R.; McIntosh, N.; Al-Dirbashi, O.Y.; Chakraborty, P.; Wheeler, A.R. "Dried Blood Spot Analysis by Digital Microfluidics Coupled to Nanoelectrospray Ionization Mass Spectrometry" Analytical Chemistry 2012, 84, 3731-3738.
  64. Luk, V.N.; Fiddes, L.K.; Luk, V.M.; Kumacheva, E.; Wheeler, A.R. "Digital Microfluidic-Hydrogel Microreactors for Proteomics" Proteomics 2012, 12, 1310-1318.
  65. Fiddes, L.K.; Luk, V.N.; Au, S.H.; Ng, A.H.C.; Luk, V.M.; Kumacheva, E.; Wheeler, A.R. "Hydrogel Discs for Digital Microfluidics" Biomicrofluidics 2012, 6, 014112.
  66. Eydelnant, I.A.; Uddayasankar, U.; Li, B.; Liao, M.W.; Wheeler, A.R. "Virtual Microwells for Digital Microfluidic Reagent Dispensing and Cell Culture" Lab on a Chip 2012, 12, 750-757.
  67. Bogojevic, D.; Chamberlain, M.D.; Barbulovic-Nad, I.; Wheeler, A.R. "A Digital Microfluidic Method for Multiplexed Cell-Based Apoptosis Assays" Lab on a Chip 2012, 12, 627-634.
  68. Srigunapalan, S.; Eydelnant I.A.; Simmons, C.A.; Wheeler, A.R. "A Digital Microfluidic Platform for Primary Cell Culture and Analysis" Lab on a Chip 2012, 12, 369-375.
  69. Kuehne, A.J.C.; Gather, M.C.; Eydelnant I.A.; Yun, S.H.; Weitz, D.A.; Wheeler, A.R. "A Switchable Digital Microfluidic Droplet Dye-Laser" Lab on a Chip 2011, 11, 3716-3719.
  70. Jebrail, M.J.; Yang, H.; Mudrik, J.M.; Lafreniere, N.M.; McRoberts, C.; Al-Dirbashi, O.Y.; Fisher, L.; Chakraborty, P.; Wheeler, A.R. "A Digital Microfluidic Method for Dried Blood Spot Analysis" Lab on a Chip 2011, 11, 3218-3224. Supporting info.
  71. Au, S.H.; Kumar, P.; Wheeler, A.R. "A New Angle on Pluronic Additives: Advancing Droplets and Understanding in Digital MicrofluidicsLangmuir 2011, 27, 8586-8594. Suppl. File 1.
  72. Yang, H.; Mudrik, J.M.; Jebrail, M.J.; Wheeler, A.R. "A Digital Microfluidic Method for in Situ Formation of Porous Polymer Monoliths with Application to Solid-Phase Extraction" Anal. Chem. 2011, 83, 3824-3830.
  73. Srigunapalan, S.; Lam, C.; Wheeler, A.R.; Simmons, C.A. "A Microfluidic Membrane Device to Mimic Critical Components of the Vascular Microenvironment" Biomicrofluidics, 2011, 5, 013409.
  74. Shih, S.C.C.; Fobel, R.; Kumar, P.; Wheeler, A.R. "A Feedback Control System for High-Fidelity Digital MicrofluidicsLab Chip, 2011, 11, 535-540. Suppl. File 1Suppl. File 2.
  75. Au, S.H.; Shih, S.C.C.; Wheeler, A.R. "Integrated Microbioreactor for Culture and Analysis of Bacteria, Algae and YeastBiomed. Microdev., 2011, 13, 41-50.
  76. Miller, E.M.; Ng, A.H.C.; Uddayasankar, U.; Wheeler, A.R. "A Digital Microfluidic Approach to Heterogeneous ImmunoassaysAnal. Bioanal. Chem., 2010, 399, 337-345.
  77. Kirby, A.E.; Jebrail, M.J., Yang, H.; Wheeler, A.R. "Folded Emitters for Nanoelectrospray Ionization Mass SpectrometryRapid Comm. Mass Spec., 2010 24, 3425–3431.
  78. Jebrail, M.J.; Ng, A.H.C.; Rai, V.; Hili, R.; Yudin, A.K.; Wheeler, A.R. "Synchonized Synthesis of Peptide-Based Macrocycles by Digital MicrofluidicsAngew. Chemie. Int. Ed., 2010, 49, 8625-8629. Supporting Info
  79. Watson, M.W.L.; Jebrail, M.J.; Wheeler, A.R. "Multilayer Hybrid Microfluidics: A Digital-to-Channel Interface for Sample Processing and SeparationsAnal. Chem. 2010, 82, 6680-6686.
  80. Barbulovic-Nad, I.; Au, S.; Wheeler, A.R. "A Microfluidic Platform for Complete Mammalian Cell CultureLab Chip 2010, 10, 1536-1542. Supporting Info 
  81. Fiddes, L.; Raz, N.; Srigunapalan, S.; Tumarkan, E.; Simmons, C.A.; Wheeler, A.R.; Kumacheva, E. "A Circular Cross-Section PDMS Microfluidics System for Replication of Cardiovascular Flow ConditionsBiomaterials 2010, 31, 3459-3464.
  82. Young, E.W.K.; Watson, M.W.L.; Srigunapalan, S.; Wheeler, A.R.; Simmons, C.A. "Technique for Real-Time Measurements of Endothelial Permeability in a Microfluidic Membrane Chip Using Laser-Induced Fluorescence DetectionAnal. Chem. 2010, 82, 808-816. Supporting Info
  83. Fiddes, L.; Chan, H.K.C.; Lau, B.; Kumacheva, E.; Wheeler, A.R. "Durable, Region-Specific Protein Patterning in Microfluidic ChannelsBiomaterials 2009, 31, 315-320. 
  84. Jebrail, M.J.; Luk, V.N.; Shih, S.C.C.; Fobel, R.; Ng, A.; Yang, H.; Freire, S.L.S.; Wheeler, A.R. "Digital Microfluidics for Automated Proteomic Processing" J. Vis. Res. 2009, 33,
  85. Mousa, N.A.; Jebrail, M.J.; Yang, H.; Abdegawad, M.; Metalnikov, P.; Chen, J.; Wheeler, A.R.; Casper, R.F. "Droplet-Scale Estrogen Assays in Breast Tissue, Blood, and SerumSci. Trans. Med., 2009, 1, 1ra2. Supporting Info
  86. Abdelgawad, M., Park, P.; Wheeler, A.R. "Optimization of Device Geometry in Single-Plate Digital MicrofluidicsJ. App. Phys. 2009, 105, 094506.
  87. Luk, V.N.; Wheeler, A.R. "A Digital Microfluidic Approach to Proteomic Sample ProcessingAnal. Chem. 2009, 81, 4524–4530 .
  88. Watson, M.W.L.; Mudrik, J.M.; Wheeler, A.R. "Gradient Elution in Microchannel ElectrochromatographyAnal. Chem. 2009, 81, 3851-3857.
  89. Abdelgawad, M.; Watson, M.W.L.; Wheeler, A.R. "Hybrid Microfluidics: A Digital-to-Channel Interface for In-Line Sample Processing and Chemical SeparationsLab Chip 2009, 9, 1046-1051.
  90. Yang, H.; Luk, V.N.; Abdelgawad, M.; Barbulovic-Nad, I.; Wheeler, A.R. "A World-to-Chip Interface for Digital MicrofluidicsAnal. Chem., 2009, 81, 1061-1067.
  91. Jebrail, M.; Wheeler, A.R. "A Digital Microfluidic Method for Protein Extraction by Precipitation" Anal. Chem. 2009, 81,  330-335.
  92. Fiddes, L.; Chan, H.K.C.; Wyss, K.; Simmons, C.A.; Kumacheva, E.; Wheeler, A.R. "Augmenting Microgel Flow Via Receptor-Ligand Binding in the Constrained Geometries of MicrochannelsLab Chip 2009, 9, 286-290.
  93. Abdelgawad, M.; Watson, M.W.L.; Young, E.W.K.; Mudrik, J.M.; Ungrin, M.D.; Wheeler, A.R. "Soft Lithography: Masters on DemandLab Chip 2008, 8, 1379-1385. Supporting Info
  94. Luk, V.N.; Mo, G.C.; Wheeler, A.R. "Pluronic Additives: A Solution to Sticky Problems in Digital MicrofluidicsLangmuir 2008, 24, 6382-6389. Supporting Info
  95. Freire, S.L.S.; Yang, H.; Wheeler, A.R. "A Practical Interface for Microfluidics and Nanoelectrospray Mass SpectrometryElectrophoresis 2008, 29, 1836-1843.
  96. Abdelgawad M.; Freire S.; Yang H.; Wheeler A. R. "All-Terrain Droplet ActuationLab Chip 2008, 8, 672-677.  Supporting Info
  97. Barbulovic-Nad, I.; Yang, H.; Park, P.S.; Wheeler, A.R. "Digital Microfluidics for Cell-Based Assays" Lab Chip 2008, 8, 519-526.
  98. Miller, E.M.; Wheeler, A.R. "A Digital Microfluidic Approach to Homogeneous Enzyme Assays" Anal. Chem. 2008, 80, 1614-1619.
  99. Abdelgawad, M.; Wheeler, A.R. "Low-Cost, Rapid-Prototyping of Digital Microfluidics Devices"Microfl. and Nanofl. 2008, 4, 349-355.
  100. Young, E.W.K.; Wheeler, A.R.; Simmons, C.A. "Matrix-Dependent Adhesion of Vascular and Valvular Endothelial Cells in Microfluidic ChannelsLab Chip, 2007, 7, 1759-1756.
  101. Fiddes, L.; Young, E.W.K.; Kumacheva, E.; Wheeler, A.R. "Flow of Microgel Capsules through Topographically Patterned MicrochannelsLab Chip 2007, 7, 863-867.
  102. Qin, J.; Wheeler, A.R. "Maze Exploration and Learning in C. elegansLab Chip 2007, 7, 186-192.
  103. Abdelgawad, M.; Wheeler, A.R. "Rapid Prototyping in Copper Substrates for Digital Microfluidics" Adv. Mater. 2007, 19, 133-137.
  104. Watson, M.; Abdelgawad, M.; Ye, G.; Yonson, N.; Trottier, J.; Wheeler, A.R. "Micro-Contact Printing-Based Fabrication of Digital Microfluidic DevicesAnal. Chem. 2006, 78, 7877-7885.

Book Chapters and Review Papers:

Return to Primary Publications
  1. Zhong, J.; Riordon, J.; Wu, T.C.; Edwards, H.; Wheeler, A.R.; Pardee, K.; Aspuru-Guzik, A.; Sinton, D. "When Robotics Met Fluidics" Lab Chip 2020, 20, 709-716.
  2. Dryden, M.D.M.; Fobel, R.; Fobel, C.; Wheeler, A.R. "Upon the Shoulders of Giants: Open-Source Hardware and Software in Analytical Chemistry" Anal. Chem. 2017, 89, 4330−4338.
  3. Dixon, C.; Lamanna, J.; Wheeler, A.R. "Printed Microfluidics" Adv. Func. Mater. 2017, 27, 1604824.
  4. Ng, A.H.C.; Li, B.; Chamberlain, M.D.; Wheeler, A.R. "Digital Microfluidic Cell Culture" Annu. Rev. Biomed. Eng. 2015, 17, 91-112.
  5. Rackus, D.G.; Shamsi, M.H.; Wheeler, A.R. "Electrochemistry, Biosensors and Microfluidics: A Convergence of Fields" Chem. Soc. Rev. 2015, 44, 5320-5340.
  6. Kirby, A.E.; Wheeler, A.R. "Digital Microfluidics: An Emerging Sample Preparation Platform for Mass Spectrometry" Anal. Chem. 2013, 85, 6178-6184.
  7. Choi, K.; Ng, A.H.C.; Fobel, R.; Wheeler, A.R. "Digital MicrofluidicsAnnu. Rev. Anal. Chem. 2012, 5, 413–440.
  8. Jebrail, M.J.; Wheeler, A.R. "Let's Get Digital: Digitizing Chemical Biology with MicrofluidicsCurr. Opin. Chem. Biol., 2010, 14, 574-581.
  9. Ng, A.H.C.; Uddayasankar, U.; Wheeler, A.R. "Immunoassays in Microfluidic Systems" Anal. and Bioanal. Chem. 2010, 397, 991-1007.
  10. Abdelgawad, M.; Wheeler, A.R. "The Digital Revolution: A New Paradigm for MicrofludicsAdv.  Mat. 2009, 21, 920-925.
  11. Miller, E.M.; Wheeler, A.R. "Digital BioanalysisAnal. and Bioanal. Chem. 2009, 393, 419-426.
  12. Wheeler, A.R. "Chemistry: Putting Electrowetting to WorkScience 2008, 322, 539-540.
  13. Charon, L.; Wheeler, A.R.; Lilge, L. "Single-Cell Analysis in Microfluidics" In Encyclopedia of Micro- and Nanofluidics; Li, D. Q., Ed.; Springer: Heidelberg, Germany, 2008; Vol. 3, pp 1851-1859.
  14. Miller, E.M.; Freire, S.L.S.; Wheeler, A.R. "Proteomics in Microfluidic Devices" In Encyclopedia of Micro- and Nanofluidics; Li, D. Q., Ed.; Springer: Heidelberg, Germany, 2008; Vol. 3, pp 1749-1758.
  15. Freire, S.L.S.; Wheeler, A.R. "Interfaces between Microfluidics and Mass Spectrometry" In Encyclopedia of Micro- and Nanofluidics; Li, D. Q., Ed.; Springer: Heidelberg, Germany, 2008; Vol. 2, pp 849-854.
  16. Barbulovic-Nad, I.; Wheeler, A.R. "Cell Assays in Microfluidics" In Encyclopedia of Micro- and Nanofluidics; Li, D. Q., Ed.; Springer: Heidelberg, Germany, 2008; Vol. 1, pp 209-216.
  17. Barbulovic-Nad, I.; Lucente, M.; Sun, Y.; Wheeler, A.R.; Bussmann, Z. "Bio-Microarray Fabrication TechniquesCrit. Rev. Biotech. 2006, 26, 237-259.
  18. Freire, S.; Wheeler, A.R. "Proteome-on-a-Chip: Mirage, or on the Horizon?Lab Chip 2006, 6, 1415-1423.